Professor
Applied Oral Sciences & Community Dental Care
Gao, Peng(高鵬)
BSc(BNU), MMed(PUMC), PhD(HKU)
Title

Assistant Professor
助理教授

Division
Applied Oral Sciences & Community Dental Care
E-mail
gaopeng@hku.hk 
Phone
+852 2859 0494 
Research Theme
Microbiome Innovation
Areas of Research Expertise
Bacterial Pathogenic Mechanism
Biofilm

Discovery of Alternative Therapeutics

Microbiome and Antibiotic Resistance

Phage Engineering

Research Profile
HKU SCHOLARS HUB→
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Publication & Awards
Publications

Article

Gao Peng, Hou Suying, Wang Peirong, Wei Yuanxin, Prakash Pradeep Halebeedu, Lai Ivan Pok Man, Yan Bingpeng, Tai Sherlock Shing Chiu, Tang Victor Yat Man, Ye Sen, Yam Bill Hin Cheung, Zhang Baozhong, Fung King Chun, Sze Kong Hung, Yang Dan, Huang Jiandong, Kao Richard Yi Tsun. Flufenamic acid fosters bacterial clearance by inhibiting Staphylococcus aureus AgrA and NLRP3 inflammasome of phagocytes, Microbiological Research 2026; 305 doi:10.1016/j.micres.2025.128434

Zhang Jing, Li Dongsheng, Zhou Wenwen, Liu Chao, Wang Peirong, You Baoqing, Su Bingjie, Guo Keyu, Shi Wenjing, Yung Tin Mong Timothy, Kao Richard Yi Tsun, Gao Peng, Li Yan, Si Shuyi. Yeast-two-hybrid based high-throughput screening to discover SARS-CoV-2 fusion inhibitors by targeting the HR1/HR2 interaction, Acta Pharmaceutica Sinica B 2025; doi:10.1016/j.apsb.2025.06.029

Ip Tiffany Ka Yan, Wang Yuchuan, Wang Suyu, Pu Keyuan, Wang Runming, Han Bingjie, Gao Peng, Xie Yanxuan, Kao Richard Y., Ho Pak Leung, Li Hongyan, Sun Hongzhe. Hinokitiol potentiates antimicrobial activity of bismuth drugs: a combination therapy for overcoming antimicrobial resistance, RSC Medicinal Chemistry 2025; 16(4): 1829-1841 doi:10.1039/d4md00860j

Li Jingru, Wang Haibo, Gao Peng, Wang Runming, Chan Chun Lung, Kao Richard Yi-Tsun, Li Hongyan, Sun Hongzhe. Bismuth drug eradicates multi-drug resistant Burkholderia cepacia complex via aerobic respiration, Chemical Science 2025; 16(27): 12372-12384 doi:10.1039/d5sc02049b

Bian Cong, Shi Wenjing, Zhao Shuwen, Li Bingchen, Yuan Min, Gao Peng, Li Yan, Si Shuyi, Chen Xiaofang. Synthesis, biological evaluation, and mechanistic investigation of tetrahydrothieno[2,3-c]pyridine derivatives as anti-Gram-negative bacterial agents, European Journal of Medicinal Chemistry 2025; 301 doi:10.1016/j.ejmech.2025.118179

Conference Paper

Gao P, Sun H, Davies J, Kao RYT. Alternative strategies to tackle antibiotics resistance, 2018 World Life Science Conference 2018;

Kao RYT, Gao P. Identification of anti-virulence compounds for combating Staphylococcus aureus infections by highthroughput screening (HTS), International Conference on Prevention & Infection Control 2017;

Gao P, Kao RYT. Disarming the protective pigments of Staphylococcus aureus by a small molecule compound, The Official Conference of the International Chemical Biology Society (ICBS) 2017;

Gao P, Wang Y, Villanueva I, Ho PL, Davies J, Kao RYT. Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression, World Life Science Conference, WLSC2016 2016;

PG Thesis

Gao Peng Small molecule compounds perturbing the virulence of Staphylococcus aureus : a chemical genetics approach[PG Thesis]. Pokfulam, Hong Kong: The University of Hong Kong; 2014. doi:10.5353/th_991044046694903414

Honours & Awards
2024. WEI Xueying, Sun H, Li H, Gao P, Xia Y. Best poster award in the 11th Asian Biological Inorganic Chemistry Conference.

2017. Kao RYT, Gao P. Innovation Academy AwardInternational Consortium on Prevention and Infection Control (ICPIC).

Professional Societies
12/2012: member. the Hong Kong Society for Infectious Diseases.  

09/2017-: member. International Chemical Biology Society (ICBS).  

07/2021-: member. American Society for Microbiology.  

03/2024-: Guest editor. Antibiotics.  

01/2025-: reviewing editor. Microbiology spectrum.  

Grants
Project Title: Development of Inhibitors Targeting the SaeRS Two-component System of Staphylococcus Aureus
Grant Type: Guangdong Basic and Applied Basic Research Fund (Guangdong Natural Science Fund) General Programme - 2024
Funding Year: 2025
Amount: HK$109,200
Principal Investigator: Professor Gao, Peng

Project Title: Bismuth(III) compounds to enhance antimicrobial activity of multiple antibiotics against Pseudomonas aeruginosa
Grant Type: General Research Fund (GRF) 2025/26
Funding Year: 2025
Amount: HK$1,219,899
Principal Investigator: Professor Sun, Hongzhe
Co-investigator(s): Professor Gao Peng

Project Title: Exploring Human Microbiota's Biosynthetic Potential for Antimicrobial Discovery
Grant Type: Collaborative Research Fund (CRF) - Group Research Project 2024/2025
Funding Year: 2024
Amount: HK$6,818,584
Principal Investigator: Professor Li, Yongxin Philip
Co-investigator(s): Professor Gao Peng, Professor Li Xuechen

Project Title: Decrypting the mechanism of anti-virulence compound HR3744 against MRSA by targeting the response regulator SaeR
Grant Type: Health and Medical Research Fund - Full Grant
Funding Year: 2019
Amount: HK$1,349,656
Principal Investigator: Professor Gao, Peng
Co-investigator(s): Dr Sze Kong Hung, Professor Hao Quan, Professor Kao Richard Yi Tsun, Professor Li Xuechen

Invited Lectures & Keynote Speeches

14 December 2023: SaeRS mediated staphylococcal biofilm formation on biotic surface.

HKU Committee Appointments
01 January 2026-Present: Discontinuation, Committee on. 1 member from each Faculty (Dentistry) from a panel of three in order of precedence for a period of 2 years, renewable up to a maximum of 4 consecutive years

11 March 2024-Present: Faculty of Dentistry, Board of the. The teachers who are members of the Faculty and who are full-time employees of the University

Note
All publication and awards data are automatically fetched periodically from the HKU Scholars Hub.
Work in the GP lab is supported by
The University of Hong Kong
Faculty of Dentistry
Research Grants Council (RGC)
Health and Medical Research Fund (HMRF)
Guangdong Natural Science Fund (GNSF)
Antenovus Biotechnology Limited
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