Equal contributions indicated with asterisk*
Corresponding author(s) indicated with bold
Publications
2026
Bismuth drug as antibiotic adjuvant to inhibit biofilm formation via a dual mechanism

Jingru Li, Peng Gao, Richard Yi-Tsun Kao, Hongyan Li, Hongzhe Sun*

RSC Medicinal Chemistry (2026): 10.1039/D6MD00204H

Flufenamic acid fosters bacterial clearance by inhibiting Staphylococcus aureus AgrA and NLRP3 inflammasome of phagocytes

Peng Gao*, Suying Hou, Peirong Wang, Yuanxin Wei, Pradeep Halebeedu Prakash, Ivan Pok Man Lai, Bingpeng Yan, Sherlock Shing Chiu Tai, Victor Yat Man Tang, Sen Ye, Bill Hin Cheung Yam, Baozhong Zhang, King Chun Fung, Kong Hung Sze, Dan Yang, Jiandong Huang, Richard Yi Tsun Kao*

Microbiological Research (2025): 128434 10.1016/j.micres.2025.128434


Biochemical-knowledge-driven machine learning pipeline for generating potent antimicrobial peptides
Deliang Yang, Yifan Li, Chenxi Li, Qingpeng Zhang, Jiandong Huang, Xue Li*, Peng Gao*
Briefings in Bioinformatics, 2026, 27(2), p.bbag115. 10.1093/bib/bbag115
Design, Synthesis, and Anti-Biofilm Activity of C-28 Modified Betulinic Acid Derivatives Targeting SarA in Drug-Resistant Staphylococcus aureus
Dongshun Jia, Junchao Zhang, Xuejin Zhang, Peng Gao, Hongyu Zhan, Zihan Dong, Hao Li, Fanhao Meng, Nan Cai, Dajun Zhang
Microorganisms 14, no. 3 (2026): 574. 10.3390/microorganisms14030574
Global emergence and evolution of Staphylococcus aureus clonal complex 59
Shuo Jiang, Peng Gao, Ping Shen, Suying Hou, Chenlu Xiao, Richard Yi Tsun Kao, Pak-Leung Ho, Yonghong Xiao, Huiluo Cao
Msystems 11, no. 2 (2026): e01492-25. 10.1128/msystems.01492-25




2025

Synthesis, biological evaluation, and mechanistic investigation of tetrahydrothieno [2, 3-c] pyridine derivatives as anti-Gram-negative bacterial agents

Cong Bian, Wenjing Shi, Shuwen Zhao, Bingchen Li, Min Yuan, Peng Gao, Yan Li, Shuyi Si, Xiaofang Chen

European Journal of Medicinal Chemistry (2025): 118179. 10.1016/j.ejmech.2025.118179

A strategy to re-sensitise drug-resistant Gram-positive bacteria to oxazolidinone-class antibiotics

Qi Zhang, Yang Yang, Ying Yang, Jin Shang, Shan Su, Peng Gao, Xiao-Xiao Li, Zhao Liu, Richard Yi-Tsun Kao, Ben Chi-Bun Ko, Benjamin Thompson, Qian Zhao

EBioMedicine 119 (2025). 10.1016/j.ebiom.2025.105914 External Link

Yeast-two-hybrid based high-throughput screening to discover SARS-CoV-2 fusion inhibitors by targeting the HR1/HR2 interaction

Jing Zhang, Dongsheng Li, Wenwen Zhou, Chao Liu, Peirong Wang, Baoqing You, Bingjie Su, Keyu Guo, Wenjing Shi, Tin Mong Timothy Yung, Richard Yi Tsun Kao*, Peng Gao*, Yan Li*, Shuyi Si*

Acta Pharmaceutica Sinica B 15, no. 9 (2025): 4829-4843. 10.1016/j.apsb.2025.06.029

Bismuth drug eradicates multi-drug resistant Burkholderia cepacia complex via aerobic respiration

Jingru Li, Haibo Wang, Peng Gao, Runming Wang, Chun-Lung Chan, Richard Yi-Tsun Kao, Hongyan Li, Hongzhe Sun

Chemical Science 16, no. 27 (2025): 12372-12384. 10.1039/D5SC02049B

Hinokitiol potentiates antimicrobial activity of bismuth drugs: a combination therapy for overcoming antimicrobial resistance

Tiffany Ka-Yan Ip, Yuchuan Wang, Suyu Wang, Keyuan Pu, Runming Wang, Bingjie Han, Peng Gao, Yanxuan Xie, Richard Y Kao, Pak-Leung Ho, Hongyan Li, Hongzhe Sun

RSC Medicinal Chemistry 16, no. 4 (2025): 1829-1841. 10.1039/D4MD00860J


2024

Bismuth-based drugs sensitize Pseudomonas aeruginosa to multiple antibiotics by disrupting iron homeostasis

Yushan Xia, Xueying Wei, Peng Gao, Chenyuan Wang, Anne De Jong, Jonathan Hon Kwan Chen, María José Rodríguez-Sánchez, Alba Rodríguez-Nogales, Patricia Diez-Echave, Julio Gálvez, Federico García, Weihui Wu, Richard Yi-Tsun Kao, Hongyan Li, Rubén Cebrián, Oscar P Kuipers, Hongzhe Sun

Nature Microbiology 9, no. 10 (2024): 2600-2613. 10.1038/s41564-024-01807-6




Work in the GP lab is supported by
The University of Hong Kong
Faculty of Dentistry
Research Grants Council (RGC)
Health and Medical Research Fund (HMRF)
Guangdong Natural Science Fund (GNSF)
Antenovus Biotechnology Limited
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